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研究業績  Papers

2022

Expression and purification of DYRK1A kinase domain in complex with its folding intermediate-selective inhibitor FINDY

Kimura N, Saito K, Niwa T, Yamakawa M, Igaue S, Ohkanda J, Hosoya T, Kii I.

Protein Expr Purif. 2022 Mar 18;195-196:106089. doi: 10.1016/j.pep.2022.106089.

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The Capsid (ORF2) Protein of Hepatitis E Virus in Feces Is C-Terminally Truncated

Nishiyama T, Umezawa K, Yamada K, Takahashi M, Kunita S, Mulyanto, Kii I, Okamoto H.

Pathogens. 2021 Dec 26;11(1):24. doi: 10.3390/pathogens11010024.

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Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A

Miyazaki Y, Kikuchi M, Umezawa K, Descamps A, Nakamura D, Furuie G, Sumida T, Saito K, Kimura N, Niwa T, Sumida Y, Umehara T, Hosoya T, Kii I.

Eur J Med Chem. 2022 Jan 5;227:113948. doi: 10.1016/j.ejmech.2021.113948. 

2021

S1PR3–G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation

Toyomoto M, Inoue A, Iida K, Denawa M, Kii I, Ngako Kadji FM, Kishi T, Im D, Shimamura T, Onogi H, Yoshida S, Iwata S, Aoki J, Hosoya T, Hagiwara M.

Cell Chemical Biology. 2021 Feb 2:S2451-9456(21)00004-0. doi: 10.1016/j.chembiol.2021.01.004.

2020

Assembly of four modules onto a tetraazide platform by consecutive 1,2,3-triazole formations.

Yoshida S, Sakata Y, Misawa Y, Morita T, Kuribara T, Ito H, Koike Y, Kii I, Hosoya T.

Chem Commun (Camb). 2020 Dec 24. doi: 10.1039/d0cc07789e. 

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Identification of synthetic inhibitors for the DNA binding of intrinsically disordered circadian clock transcription factors.

Hosoya Y, Nojo W, Kii I, Suzuki T, Imanishi M, Ohkanda J.

Chem Commun (Camb). 2020 Sep 24;56(76):11203-11206. doi: 10.1039/d0cc04861e.

 

Indolizines Enabling Rapid Uncaging of Alcohols and Carboxylic Acids by Red Light-Induced Photooxidation.

Watanabe K, Terao N, Kii I, Nakagawa R, Niwa T, Hosoya T.

Org Lett. 2020 Jul 17;22(14):5434-5438. doi: 10.1021/acs.orglett.0c01799. 

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HaloTag-based conjugation of proteins to barcoding-oligonucleotides.

Yazaki J, Kawashima Y, Ogawa T, Kobayashi A, Okoshi M, Watanabe T, Yoshida S, Kii I, Egami S, Amagai M, Hosoya T, Shiroguchi K, Ohara O.

Nucleic Acids Res. 2020 Jan 24;48(2):e8. doi: 10.1093/nar/gkz1086.

2019

Screening of novel drugs for inhibiting hepatitis E virus replication.

Nishiyama T, Kobayashi T, Jirintai S, Kii I, Nagashima S, Prathiwi Primadharsini P, Nishizawa T, Okamoto H.

J Virol Methods. 2019 Aug;270:1-11. doi: 10.1016/j.jviromet.2019.04.017.

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A facile preparation of functional cycloalkynes via an azide-to-cycloalkyne switching approach.

Yoshida S, Kuribara T, Ito H, Meguro T, Nishiyama Y, Karaki F, Hatakeyama Y, Koike Y, Kii I, Hosoya T.

Chem Commun (Camb). 2019 Mar 19;55(24):3556-3559. doi: 10.1039/c9cc01113g.

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Alzheimer Aβ Assemblies Accumulate in Excitatory Neurons upon Proteasome Inhibition and Kill Nearby NAKα3 Neurons by Secretion.

Komura H, Kakio S, Sasahara T, Arai Y, Takino N, Sato M, Satomura K, Ohnishi T, Nabeshima YI, Muramatsu SI, Kii I, Hoshi M.

iScience. 2019 Mar 29;13:452-477. doi: 10.1016/j.isci.2019.01.018.

2018

Staudinger reaction using 2,6-dichlorophenyl azide derivatives for robust aza-ylide formation applicable to bioconjugation in living cells.

Meguro T, Terashima N, Ito H, Koike Y, Kii I, Yoshida S, Hosoya T.

Chem Commun (Camb). 2018 Jul 12;54(57):7904-7907. doi: 10.1039/c8cc00179k.

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Quantification of receptor activation by oxytocin and vasopressin in endocytosis-coupled bioluminescence reduction assay using nanoKAZ.

Kii I, Hirahara-Owada S, Yamaguchi M, Niwa T, Koike Y, Sonamoto R, Ito H, Takahashi K, Yokoyama C, Hayashi T, Hosoya T, Watanabe Y.

Anal Biochem. 2018 May 15;549:174-183. doi: 10.1016/j.ab.2018.04.001.

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Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions.

Yoshida S, Kanno K, Kii I, Misawa Y, Hagiwara M, Hosoya T.

Chem Commun (Camb). 2018 Apr 10;54(30):3705-3708. doi: 10.1039/c8cc01195h.

2017

Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice.

Nakano-Kobayashi A, Awaya T, Kii I, Sumida Y, Okuno Y, Yoshida S, Sumida T, Inoue H, Hosoya T, Hagiwara M.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10268-10273. doi: 10.1073/pnas.1704143114.

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Direct reprogramming of fibroblasts into skeletal muscle progenitor cells by transcription factors enriched in undifferentiated subpopulation of satellite cells.

Ito N, Kii I, Shimizu N, Tanaka H, Takeda S.

Sci Rep. 2017 Aug 14;7(1):8097. doi: 10.1038/s41598-017-08232-2.

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DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain.

Abu Jhaisha S, Widowati EW, Kii I, Sonamoto R, Knapp S, Papadopoulos C, Becker W.

Sci Rep. 2017 Jul 25;7(1):6420. doi: 10.1038/s41598-017-06874-w.

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Three-Dimensional Localization of an Individual Fluorescent Molecule with Angstrom Precision.

Furubayashi T, Motohashi K, Wakao K, Matsuda T, Kii I, Hosoya T, Hayashi N, Sadaie M, Ishikawa F, Matsushita M, Fujiyoshi S.

J Am Chem Soc. 2017 Jul 5;139(26):8990-8994. doi: 10.1021/jacs.7b03899.

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Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy.

Sako Y, Ninomiya K, Okuno Y, Toyomoto M, Nishida A, Koike Y, Ohe K, Kii I, Yoshida S, Hashimoto N, Hosoya T, Matsuo M, Hagiwara M.

Sci Rep. 2017 May 30;7:46126. doi: 10.1038/srep46126.

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Downregulation of neuropilin-1 on macrophages modulates antibody-mediated tumoricidal activity.

Kawaguchi K, Suzuki E, Nishie M, Kii I, Kataoka TR, Hirata M, Inoue M, Pu F, Iwaisako K, Tsuda M, Yamaguchi A, Haga H, Hagiwara M, Toi M.

Cancer Immunol Immunother. 2017 Sep;66(9):1131-1142. doi: 10.1007/s00262-017-2002-2.

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Periostin is required for matricellular localization of CCN3 in periodontal ligament of mice.

Takayama I, Tanabe H, Nishiyama T, Ito H, Amizuka N, Li M, Katsube KI, Kii I, Kudo A.

J Cell Commun Signal. 2017 Mar;11(1):5-13. doi: 10.1007/s12079-016-0371-5.

2016

Periostin Deficiency Causes Severe and Lethal Lung Injury in Mice With Bleomycin Administration.

Kondoh H, Nishiyama T, Kikuchi Y, Fukayama M, Saito M, Kii I, Kudo A.

J Histochem Cytochem. 2016 Jul;64(7):441-53. doi: 10.1369/0022155416652611.

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Selective inhibition of the kinase DYRK1A by targeting its folding process.

Kii I, Sumida Y, Goto T, Sonamoto R, Okuno Y, Yoshida S, Kato-Sumida T, Koike Y, Abe M, Nonaka Y, Ikura T, Ito N, Shibuya H, Hosoya T, Hagiwara M.

Nat Commun. 2016 Apr 22;7:11391. doi: 10.1038/ncomms11391.

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Periostin promotes secretion of fibronectin from the endoplasmic reticulum.

Kii I, Nishiyama T, Kudo A.

Biochem Biophys Res Commun. 2016 Feb 19;470(4):888-93. doi: 10.1016/j.bbrc.2016.01.139.

2015

Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ.

Sonamoto R, Kii I, Koike Y, Sumida Y, Kato-Sumida T, Okuno Y, Hosoya T, Hagiwara M.

Sci Rep. 2015 Aug 3;5:12728. doi: 10.1038/srep12728.

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Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly.

Ohnishi T, Yanazawa M, Sasahara T, Kitamura Y, Hiroaki H, Fukazawa Y, Kii I, Nishiyama T, Kakita A, Takeda H, Takeuchi A, Arai Y, Ito A, Komura H, Hirao H, Satomura K, Inoue M, Muramatsu S, Matsui K, Tada M, Sato M, Saijo E, Shigemitsu Y, Sakai S, Umetsu Y, Goda N, Takino N, Takahashi H, Hagiwara M, Sawasaki T, Iwasaki G, Nakamura Y, Nabeshima Y, Teplow DB, Hoshi M.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):E4465-74. doi: 10.1073/pnas.1421182112.

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Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis.

Masaki S, Kii I, Sumida Y, Kato-Sumida T, Ogawa Y, Ito N, Nakamura M, Sonamoto R, Kataoka N, Hosoya T, Hagiwara M.

Bioorg Med Chem. 2015 Aug 1;23(15):4434-41. doi: 10.1016/j.bmc.2015.06.018.

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Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice.

Morooka S, Hoshina M, Kii I, Okabe T, Kojima H, Inoue N, Okuno Y, Denawa M, Yoshida S, Fukuhara J, Ninomiya K, Ikura T, Furuya T, Nagano T, Noda K, Ishida S, Hosoya T, Ito N, Yoshimura N, Hagiwara M.

Mol Pharmacol. 2015 Aug;88(2):316-25. doi: 10.1124/mol.114.097345.

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